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Mayo Clinic researchers prove key cancer theory

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Childhood cancer survivors experience suicidal thoughts decades after diagnosis
'Hygiene hypothesis' challenged
Heavy drinkers face significantly increased cancer risk
High-fat low-carb diets could mean significant heart risk
Most women unaware of risk for debilitating fractures
Chemical presence in your Christmas presents?
Toward a nanomedicine for brain cancer
Less sleep may add up to more pounds in adolescents
Lack of morning light keeping teenagers up at night
Bathing and showering: Underappreciated sources of water pollution from medicines
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A drug-dispensing contact lens now possible
Smoking during pregnancy puts children at risk of psychotic symptoms
New study finds MRSA on the rise in hospital outpatients
Exercise therapy best for knee pain
Parkinson's disease treatments associated with compulsive behaviours
The bowels of infection
Promising therapy for relapsing multiple sclerosis
The hepatitis healing power of blueberry leaves
Researchers identify method to help reduce fat in the blood
Heart Surgery Sees Dramatic Improvement Since Mortality Data Publication
Workplace bullying is associated with sleep disturbances
Microbes help mothers protect kids from allergies
Rudeness at work causes mistakes
Swine Flu Pandemic (H1N1) 2009: Advice for travellers
Coal from mass extinction era linked to lung cancer mystery
Home DNA paternity tests coming to a pharmacy near you
The sweet smell of ageing
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Americans favor conservation, but few practice it
New rabies vaccine may require only a single shot... not 6
Bacteria toxic to wound-treating maggots
Acupuncture calms highly anxious dental patients
People who work after retiring enjoy better health, according to national study
Why light worsens migraine headaches
A butterfly effect in the brain
Treating female sexual dysfunction
New research reinforces anti-inflammatory properties of tart cherries
Under 50? Silent duo could put you at risk for a big stroke
Sticking to diets is about more than willpower
High fructose corn syrup: A recipe for hypertension
New cancer gene discovered
New heart disease risk score outperforms existing test
A 'spoonful of sugar' makes the worms' life span go down
Too much selenium can increase your cholesterol
ISU study finds TV viewing, video game play contribute to kids’ attention problems
Women with diabetes at increased risk for irregular heart rhythm
Infertility and the Battle of the Sexes
How our brains can fill in the gaps to create continuous sound
Fasting prolongs reproductive life span
Findings that should speed the development of drugs for Parkinson's Disease
High Blood Pressure May Lead to ‘Silent’ Strokes
Regular use of aspirin increases risk of Crohn's disease by 5 times
UK Swine Flu Cases Reach 750
New smoking cessation therapy proves promising
Brief treatment can ease depression in mothers
UK officials issue level 2 heatwave warning
Is the disorder that causes dementia hereditary?
Chronic pain found to increase risk of falls in older adults
New cancer treatment gives hope to lymphoma and leukaemia patients
Stop and smell the flowers -- the scent really can soothe stress
Humans may give swine flu to pigs
Poor health among indigenous peoples a question of cultural loss as well as poverty
First evidence that blueberry juice improves memory in older adults
Emergency contraception: Advance provision does not reduce pregnancy rates
ACR statement on airport full-body scanners and radiation
Children with cochlear implants have quality of life equal to normal hearing peers
Vitamin D and calcium interplay explored
Overweight Kids Experience More Loneliness, Anxiety, MU Study Finds
Who is likely to become a bully, victim or both?
Why fish oils help and how they could help even more
Peaches, plums induce deliciously promising death of breast cancer cells
People affected by autism believe increase is 'real, ' not diagnostic
Tiger Bones Rejected By Chinese Medicine Societies Ahead Of CITES Conference
New device enables early detection of cancerous skin tumours
Study finds higher risk of stillbirth in women with fibroids
Evidence that nanoparticles in sunscreens could be toxic if accidentally eaten
Aspirin Misuse May Have Made 1918 Flu Pandemic Worse
Fish oil supplement study shock
Five exercises can reduce neck and shoulder pain of women office workers
Child burn injuries down significantly
Study: being active as a preschooler pays off later in childhood
Relieving pain affecting millions
Non-medical treatment may rapidly relieve severe IBS symptoms
Middle-aged men: Could dwindling testosterone levels decrease sleep?
Poor children more vulnerable to effects of poor sleep
New hope for diagnosis and treatment of intractable paediatric brain tumours
Organic food not nutritionally better than conventionally produced food
Waterpipes: A new worrying trend on the rise?
Think what you eat: Studies point to cellular factors linking diet and behaviour
Overweight middle-aged women cut chances of enjoying healthy old age
Lung virus taking its toll on young lives, study finds
At-home sleep testing equal to overnight in a sleep lab in treatment results
Smoke no longer found in European hospitals
Women often opt to surgically remove their breasts and ovaries to reduce cancer risk
Women's soccer -- get fit while having fun
LED light and green tea cream to smooth facial wrinkles
Nearly two thirds of UK adults risk their health through insufficient exercise, new survey shows
Perhaps a longer lifespan, certainly a longer 'health span'
Study demonstrates pine bark naturally reduces hay fever symptoms
Study finds partner abuse leads to wide range of health problems
High vitamin D levels linked to lower risk of colon cancer
For osteoporosis patients, exercise pill one step closer to reality
Testosterone deficiency affects male cancer survivors' quality of life
Lack of sleep could be more dangerous for women than men
The psychology of food cravings
Pharmacists Improve Care of Diabetics While Cutting Costs
Grandpa's broken hip may mean weaker bones for his grandsons
Michael J. Fox Foundation awards grant to advance Parkinson's disease research
Lower detection of prostate cancer with PSA screening in US than in a European randomised trial
Chocolate Easter Eggs could be lowering the risk of stroke!
Ebola Reston in pigs and humans in the Philippines - Update
Researchers find room design can enhance patient care
Scientists design new drug type to kill lymphoma cells
New study links vitamin D deficiency to cardiovascular disease and death
School closure could reduce swine flu transmission by 21 percent
Mouldy homes a serious risk for severe asthma attacks for some
Babies and sleep: Another reason to love naps
Organic or local?
Are Holiday and Weekend Eating Patterns Affecting Obesity Rates?
Gut acid levels determine healthy bones
US President Struggles with Habit
Teeth grinding linked to sleep apnoea
Even the boss doesn't follow the doctor's orders
Chances of surviving cardiac arrest depends on your neighbourhood
Starting treatment early doubles chance of success for people with diabetes
Breast density associated with increased risk of cancer recurrence
Cancers of sweat glands, other skin-related structures may be increasing in United States
Extended youthfulness as a prevention for Alzheimer's disease
Freshly crushed garlic better for the heart than processed
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Stem cell discovery may bring tissue repair closer
A pain in the neck
Experts call for urgent action to tackle strong links between impotence and heart disease
World-first swine-flu vaccine trial reveals one dose provides 'strong immune response'
Doctors report alarming increase in mumps-related testicle problems among young males
Alternative strategies to reduce maternal mortality in India
Study shows that elderly women sleep better than they think and men sleep worse
Acupuncture-Like Treatments Improve Outcomes Compared to Usual Care for Low Back Pain
Female athletes injured more than male athletes
Consumers over age 50 should consider steps to cut copper and iron intake
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Obesity service receives international recognition
Researchers find clues that may solve mystery of why hair turns grey
Artificial sweeteners, without the aftertaste: Scientists find bitter-blocking ingredient
4 unhealthy behaviours combine to increase death risk
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Scanning for skin cancer: Infrared system looks for deadly melanoma
Disordered eating may affect 10 to 15 percent of women
Teenage physical activity reduces risk of cognitive impairment in later life
Cheese found to improve the immune response of the elderly
Cost concerns prevent many cancer survivors from getting medical care
New diagnostic test for bladder cancer
Easy strength training exercise may help treat tennis elbow, study shows
Losing sleep, losing brain?
ATV and Motocross Sports – High Velocity Toys Merit Caution
Therapeutic effect of fermented milk on chronic gastritis
New groundbreaking treatment for oxygen-deprived newborns
Fibromyalgia symptoms improved by lifestyle adjustments
UK’s poorest twice as likely to have diabetes and its complications
Children who lose a parent to suicide more likely to die the same way
Men feel less guilt - official
5 Christmas Tips for Children with ADHD
Asthma UK issues advice on managing asthma in hot weather conditions
Daylight could help control our weight
Less than 50% of men and women with depression see a doctor for treatment
Elimination of river blindness feasible
Simple test may identify stroke survivors at risk of another cardiovascular event
Household detergents, shampoos may form harmful substance in waste water
Study finds dirty air in California causes millions worth of medical care each year
Massage eases anxiety, but no better than simple relaxation does
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Air pollution may trigger appendicitis
Meditation reduces the emotional impact of pain
Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function
Brain abnormalities in Parkinson's patients develop before symptoms occur
Researchers find clues to why some continue to eat when full
Lowering sodium consumption could save US $18 billion annually in health costs, study finds
Hair dye and smoking linked to progressive liver disease
Concerns about health and looks cause thousands to cut back on alcohol
Fruit and vegetable intake in pregnant women reduces risk of upper respiratory tract infection
Many clinicians may be screening for cervical cancer too frequently
Videoconferencing with family members enriches the lives of nursing home residents
New Evidence That Green Tea May Help Improve Bone Health
Merry Christmas and Happy Holidays from Worldwidehealth.com
Canadians lead longer, healthier lives than Americans
Delay in Diagnosis of Menopause-like Condition in Young Women Linked to Low Bone Density
Common osteoporosis drugs are associated with a decrease in risk of breast cancer
Researchers find that eating high levels of fructose impairs memory in rats
Anti-cancer compound found in American mayapple
Does an Ancient Remedy Work Better than Modern Drugs?
Will giving coffee to babies keep them awake as adults?
New Research Reveals Americans’ Strong Desire to Use Food to Improve Health
Experts warn against New Year Brain Drain
Soft drink consumption may increase risk of pancreatic cancer
TV food advertisements promote imbalanced diets
Environmental manganese good in trace amounts but can correlate to cancer rates
How high can a climber go?
Grapes reduce risk factors for heart disease and diabetes
Talking Touchscreens and Patients
Post-traumatic stress disorder diagnosed with magnetism
Cancer mortality rates experience steady decline
Study examines relationship between type of rice consumption and diabetes risk
Rhythm of life: Music shows potential in stroke rehabilitation
Man sentenced over Ł6m unlicensed and counterfeit medicines case
New form of insulin can be inhaled rather than injected
Brain's fear centre is equipped with a built-in suffocation sensor
How likely is misdiagnosis?
Should flowers be banned in hospitals?
Study shows how dietary supplement may block cancer cells
Children with asthma more vulnerable to H1N1 virus
Diet high in B-vitamins lowers heart risks in Japanese study
Healing power of aloe vera proves beneficial for teeth and gums, too
Exercise Is Healthy for Mother and Child During Pregnancy
Fast food menus with calorie information lead to lower calorie selections for young children
Beverage can stay-tabs pose swallowing risk
Mercury is higher in some tuna species
Gifted young athletes are under increasing pressure to play only one sport year round.
Special ultrasound accurately identifies skin cancer
Zebra fish journal publishes cancer biology study
Older Men With Breathing Problems During Sleep More Likely to Have Irregular Heartbeats
EU to fund complementary medicine research
Parental involvement key to preventing child bullying
Antidepressant use increasing in the United States
Faulty body clock may make kids bipolar
Higher drug doses needed to defeat tuberculosis, researchers report
Trigger of deadly food toxin discovered
Breathe easy: A natural fruit compound may help asthma
Tapping away desire for those favorite foods and snacks
Airway discovery may result in new treatment
Binge drinkers let down guard against infection
UK Swine Flu cases top 3, 250
Studying hair of ancient Peruvians answers questions about stress
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ER computer keyboards and bacteria
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Exposure to tobacco smoke in childhood home associated with early emphysema in adulthood
Men with bigger wallets have bigger waistlines
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New inherited eye disease discovered
'Poop' dermatitis linked to fashionable toilet seats, harsh chemicals
Natural S-Equol suggested as critical component for reducing menopausal hot flushes
Fats for health - Giving soybean oil a new role in serving society
Universal screening lowers risk of severe jaundice in infants
Plaque on CT scan is strong predictor of heart disease, worse long-term outcomes
Poor sleep in children may have prenatal origins
Track your festive drinking with new mobile phone application
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Driving retirement for seniors: Long overdue!
Strong link between obesity and depression
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Obesity may harm your sexual health
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Current cigarette smokers at increased risk of seizures
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New Role Discovered for Molecule Important in Development of Pancreas, US Study Finds
Number of injuries from hot tubs doubles
Studies advise on fluoridated toothpaste use in children
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Cartilage repair can improve life and ease burden on health services
Possible origins of pancreatic cancer revealed
Work-life balance: Brain stem cells need their rest, too
Modernizing the treatment of sexual dysfunction in men
Women may be dying because of diagnosis confusion
1 in 4 not covering coughs, sneezes
Getting plants to rid themselves of pesticide residues
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Sustainable fertilizer: Human urine and wood ash produce large harvest
New study shows driving hinders talking
Going to the gym shouldn't be a workout for your eardrums
A midday nap markedly boosts the brain's learning capacity
Colic In Babies May Be Caused By Gut Bacteria
The new exercise HIT: do less
New research confirms potential deadly new malaria species in humans
Restless legs syndrome appears to occur within families
Minorities hit hardest by arthritis
An innate sense of direction
New virus is not linked to chronic fatigue syndrome, suggests UK research
National autism research led by Leicester specialist
New guideline helps determine brain death in adults
Low fat dieters feel like outcasts among friends
MEN ARE almost 40 per cent more likely than women to die from cancer
Difficult childhoods lead to teenage drinking
Enjoying school key to tackling teenage pregnancy
Christmas advice from the Scottish Chiropractic Association
A role for calcium in taste perception
New link identified for bipolar disorder
Omega-3 fatty acids may reduce risk of colon cancer
Potential new test for early diagnosis of osteoarthritis identified
Study shows brief training in meditation may help manage pain
Vitamin D Supplementation for Infants
IBS patients not more likely to develop polyps or colon cancer
Does the weather cause northerners to get more prostate cancer?
New Alzheimer's test offers better opportunities for early detection
Divorce undermines health in ways remarriage doesn't heal
Raising kids may lower blood pressure
One active Christmas gift can improve your child’s health, say physios
Tomato supplement 'staves off heart disease'
New evidence that dark chocolate helps ease emotional stress
Condoms provide moderate protection against herpes simplex virus 2
Answer to saliva mystery has practical impact
Pistachios offer multiple benefits
Stillbirth numbers 'starting to fall'
Real-time Control Of Wheelchair Using Brain Waves
The first malaria-proof mosquito
Ice cream may target the brain before your hips
Some colour shades offer better protection against sun’s ultraviolet rays
Whole grain, bran intake associated with lower risk of death in diabetic women
More than 1, 000 patients in US admitted annually for aviation-related injuries
Research shows Tai Chi exercise reduces knee osteoarthritis pain in the elderly
UK families with disabled children more likely to live in poverty
Greater religiosity during adolescence may protect against developing problem alcohol use
Statutory Regulation of Practitioner Psychologists
Small amounts of lead may damage children's kidneys
Study shows potential benefit of dark chocolate for liver disease patients
Thousands at risk from hidden heart condition
New report challenges commonly held beliefs on Hay fever
Self-esteem declines sharply among older adults while middle-aged are most confident
Consulting 'Dr. Google'
The Prostate Cancer Charity Comments On Research Into The Effects Of Green Tea On Men Diagnosed With Prostate Cancer
Most antidepressants miss key target of clinical depression
Muscle loss finding may one day save physiques
Pregnant women who are overweight put their infants at risk
Hand and feet massages provide consolation for bereaved relatives
Portable media players associated with short-term hearing effects
New Material Mimics Bone To Create Better Biomedical Implants
Smokers at risk from their own 'second-hand' smoke
Restaurant and packaged foods can have more calories than nutrition labeling indicates
Common anti-inflammatory drug could help prevent skin cancers
Pesticides – easier detection of pollution and impact in rivers
Alcohol consumption in Portugal: The burden of disease
Eating foods rich in vitamin E associated with lower dementia risk
Pinhead-size worms + robot = new antibiotics
Ironing out the causes of wrinkles
Harm caused by nicotine withdrawal during intensive care
Tai Chi gets cautious thumbs up for psychological health
Human sperm created from embryonic stem cells
Protein level may serve as predictor of severe osteoarthritis
Early menopause linked to higher risk of future cardiovascular disease
Switch programme increases children's healthy eating
Bright Light Therapy Improves Sleep Disturbances in Soldiers with Combat PTSD
Christmas desserts on your mind? Your muscles may be getting the message
Link found between passive smoking and poorer mental health
Only the beautiful need apply
Landmark trial finds stents as good as surgery for unclogging carotid arteries
Rapid flu testing
Trials begin on potent new hepatitis C drug
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Scottish people 'living dangerously'
Probiotics help extremely premature infants gain weight
Killed by cold: heart and stroke deaths peak in winter
Stain repellent chemical linked to thyroid disease in adults
Institute for Aging Research study links high-heels to heel and ankle pain
UK Swine Flu Cases Double in Just Five Days
High salt intake linked to strokes and cardiovascular disease
Self-monitoring of blood glucose
Each pound at birth lowers risk of developing TB
Rheumatoid services 'are failing' in the UK
Parents' physical inactivity influences children
Public say mental health problems deserve sympathy
Scientists discover new treatment for chronic pain condition
Knee injuries may start with strain on the brain, not the muscles
40 percent of surface disinfectants ineffective in eliminating viruses that cause gastroenteritis
Natural Compound Stops Diabetic Retinopathy
Work conditions impact parents' food choices
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Video Study Finds Risky Food-Safety Behaviour More Common Than Thought
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Ovary removal may increase lung cancer risk
Exercise reduces death rate in prostate cancer patients
Evidence shows over age 50 users should cut copper and iron intake
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Sexually satisfied women have better general well-being and more vitality
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High-fat diet affects physical and memory abilities of rats after 9 days
Mayo Clinic researchers prove key cancer theory
New research rejects 80-year theory of 'primordial soup' as the origin of life
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Spread a little Holiday care
Antidepressants in pregnancy increase risk of miscarriage
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UK incidence of children living with substance-misusing parents considerably underestimated
Reducing niacin intake can prevent obesity
Talk to your babies
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Diabetes cases to double and costs to triple by 2034
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Tags: Aneuploidy, tumour genes, cancer causes


By David Fewster - Worldwidehealth Editor

This article has been viewed 790 times.

Animal study demonstrates how whole chromosome changes cause cancer

Rochester USA -- Mayo Clinic researchers have proven the longstanding theory that changes in the number of whole chromosomes -- called aneuploidy -- can cause cancer by eliminating tumour suppressor genes.

Their findings, which appear in the current issue of the journal Cancer Cell along with an independent commentary on the discovery, end a major controversy in the field of cancer research as to whether aneuploidy is a cause or a consequence of cancer.

Virtually all human cancers have an abnormal number of chromosomes. Therefore, it has been long suspected that gene mutations which promote erroneous chromosome separation during cell division are to blame for tumour development. However, because of experimental limitations this was difficult to prove.

"By using a combination of new and established mouse models for human cancer, we were able to prove that aneuploidy causes cancer and elucidate the mechanism by which it does so," explains Jan van Deursen, Ph.D., Mayo Clinic cancer biologist and senior author.

Significance of the Research

These findings explain how chromosomal errors can cause cancer. They prove the role of aneuploidy in the elimination of genes that suppress tumour formation.

"Now that we understand the mechanism by which aneuploidy causes cancer, it will be easier for other researchers to build on this knowledge - and target new drugs accordingly," says Dr. van Deursen.

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Author: David Fewster - Worldwidehealth Editor


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