Health News - CJD/vCJD/Mad Cow Disease

Could type 2 diabetes be transmissible?
New research finds a mechanism in type 2 diabetes that is similar to a group of transmissible neurodegenerative disorders called prion disorders. (Medical News Today)

New blood test for prion disease looks promising
A new biochemical test that detects prions in blood shows promise for early, pre-symptom diagnosis of vCJD and improving safety of blood supply. (Medical News Today)

Mutant prion protein could help reveal neurodegenerative disease mechanisms
For the first time, scientists have isolated a mutated prion protein that can multiply in the lab but not in living animals, according to a PLOS Pathogens study. (Medical News Today)

Fruit fly model of deadly brain diseases could lead to blood test for vCJD
A new model of fatal brain diseases is being developed in the fruit fly by a team led by Dr Raymond Bujdoso at the University of Cambridge, and could lead to a low cost, fast and efficient blood... (Medical News Today)

A urine test to diagnose Creutzfeldt-Jakob Disease may be possible
Researchers at the Medical Research Council (MRC) Prion Unit at UCL have found that it may be possible to determine whether or not a person has sporadic Creutzfeldt-Jakob Disease (sCJD) by testing... (Medical News Today)

Cascade of events leading to prion disease described
New experiments in mice now enable researchers to evaluate disease progression and potential therapeutic interventions in vivo, according to a new report in The American Journal of Pathology. (Medical News Today)

Impact of prion proteins on the nerves revealed for the first time
When prion proteins mutate, they trigger mad cow and Creutzfeldt-Jakob disease. Although they are found in virtually every organism, the function of these proteins remained unclear. (Medical News Today)

How prions kill neurons: new culture system shows early toxicity to dendritic spines
Prion diseases are fatal and incurable neurodegenerative conditions of humans and animals. Yet, how prions kill nerve cells (or neurons) remains unclear. (Medical News Today)

New assay offers improved detection of deadly prion diseases
Timed amyloid seeding assay achieves or surpasses sensitivity of currently available tests for transmissible spongiform encephalopathies, according to a report in The Journal of Molecular Diagnostics. (Medical News Today)

It's complicated: benefits and toxicity of anti-prion antibodies in the brain
Immunotherapy to ameliorate neurodegeneration by targeting brain protein aggregates with antibodies is an area of intense investigation. (Medical News Today)

Alzheimer-type brain pathology after transplantation of dura mater
Up to now Alzheimer's disease has not been recognised as transmissible. Now researchers at the University of Zurich and the Medical University Vienna demonstrated Alzheimer-type pathology in brains... (Medical News Today)

Parkinson's disease: New insights into a traveling protein
A laboratory study indicates that one of the main proteins involved in Parkinson's disease pathology does not behave as a 'prion' In Parkinson's disease, the protein "alpha-synuclein" aggregates... (Medical News Today)

Alzheimer's may be a collection of diseases that should be treated separately
It is essential to carefully characterize and classify the mechanisms that underlie Alzheimer's disease, in order to allow for the development of novel therapies that can be prescribed according to... (Medical News Today)

From good to bad with a copper switch: Here's the mechanism that creates prions, the 'bad' proteins
At the molecular level, the difference between Doctor Jekyll and Mr Hyde lies in a metal, copper. (Medical News Today)

Prion disease detected soon after infection and in surprising place in mouse brains
Prion diseases--incurable, ultimately fatal, transmissible neurodegenerative disorders of mammals--are believed to develop undetected in the brain over several years from infectious prion protein. (Medical News Today)

Finding a way forward in the fight against prion disease
UAlberta study finds bile acids may prolong survival in models of prion diseaseFor much of her adult life Valerie Sim has been fascinated by a disease very few in the world can claim to even... (Medical News Today)

New type of prion may cause, transmit neurodegeneration
Multiple System Atrophy (MSA), a neurodegenerative disorder with similarities to Parkinson's disease, is caused by a newly discovered type of prion, akin to the misfolded proteins involved in... (Medical News Today)

Sequestered prion protein takes the good mood away, suggests new hypothesis on depression
The discovery of antidepressant drugs in the 1950s led to the first biochemical hypothesis of depression, known as the monoamine hypothesis. (Medical News Today)

Why it's hard to make a bunny mad: examining prion disease resistance in rabbits
Rabbits have long been considered immune to prion disease, but recently scientists have shown that they can - under certain circumstances - get transmissible spongiform encephalopathy (or TSE, the... (Medical News Today)

Brain infection study reveals how disease spreads from gut
Research could enable earlier detection of prion diseasesThis magnified image of the small intestine shows specialized structures called Peyer's patches -- which are part of the body's immune... (Medical News Today)

Prion trials and tribulations: Finding the right tools and experimental models
Prions are fascinating, enigmatic, and might teach us not only about rare prion diseases like Creutzfeld-Jakob disease, mad cow disease, or scrapie, but also about other more common neurodgenerative... (Medical News Today)

Solving the next step in the mystery of prions
UAlberta scientists aim to understand how proteins convert from a normal structure to a diseased stateWorking towards the ultimate goal to develop therapeutics to treat diseases such as... (Medical News Today)

'Cannibal disease' study pinpoints gene responsible for CJD resistance
Researchers investigating kuru, a brain disease associated with cannibalism, have discovered a genetic mutation that provided mice with resistance to both the disease and CJD. (Medical News Today)

Naturally occurring genetic variation gives complete resistance in prion diseases
Researchers at the Medical Research Council's Prion Unit have identified a naturally occurring variant of the human prion protein that produces resistance to prion diseases such as... (Medical News Today)

UTHealth research: Grass plants can transport infectious prions
Grass plants can bind, uptake and transport infectious prions, according to researchers at The University of Texas Health Science Center at Houston (UTHealth). (Medical News Today)

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