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Tue, 13 Oct 2015, 05:00 GMT

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Health News - Genetics

Ablation of purinoceptor P2RX7 ameliorates DMD-like phenotypes in a mouse model
Genetic ablation of P2RX7 can improve muscle function and partially correct cognitive impairment and bone loss in a mouse model of Duchenne muscular dystrophy (DMD), according to a study published... (Medical News Today)

"Indefatigable Hearing" - a molecular clearance mechanism enables synapses to continously release transmitter
Disabling hearing impairment (HI) affects 360 million people worldwide, and prevalence increases with age. So far, no causal treatment is available for its most common form, sensorineural HI. (Medical News Today)

IU scientists find the external environment, oxidation greatest threats to DNA
Bacterium exhibits remarkable ability to repair or prevent DNA damage arising from internal processes, contrary to previous findingsThe rod-shaped bacterium E. (Medical News Today)

Prostate cells undergo 'reprogramming' to form tumors, study finds
Scientists have gained a key insight into how prostate tumors get their start - not by rewriting the normal DNA code, but by reprogramming the master regulator of genes in prostate cells to drive... (Medical News Today)

Penn study stops vision loss in late-stage canine X-linked retinitis pigmentosa
Three years ago, a team from the University of Pennsylvania announced that they had cured X-linked retinitis pigmentosa, a blinding retinal disease, in dogs. (Medical News Today)

RNA editing technique treats severe form of muscular dystrophy
A family's diagnosis helps drive discovery to slow decline in muscle function Father, whose two sons have the disease, encourages scientist to try technique Dr. (Medical News Today)

New research sees zebrafish earn their stripes in the fight against Muscular Dystrophy
New research published in the journal eLife has demonstrated a new method for observing the behaviour of the protein Dystrophin in a living animal cell, in real-time. (Medical News Today)

Comprehensive genomic study provides evidence that dengue has become endemic and diverse in China
Study suggests dengue can persist year-round in China, increasing the risk of more frequent and severe outbreaksThe first-ever comprehensive genomic analysis of the virus that causes dengue fever... (Medical News Today)

First comprehensive profile of non-protein-coding RNAs in human cancers
Provides clinicians with new way to diagnose array of cancersGrowing insights about a significant, yet poorly understood, part of the genome - the "dark matter of DNA" -- have fundamentally... (Medical News Today)

Scientists convert skin cells into placenta-generating cells
Regenerative medicine is a new and expanding area that aims to replace lost or damaged cells, tissues or organs in the human body through cellular transplantation. (Medical News Today)

Scientists find cause of reduced drug sensitivity in HER2-positive breast cancer
In the presence of the HER2 inhibitor lapatinib, the tumor suppressor molecule FOXO changes role and desensitizes HER2+ breast cancer cells to the drug, leading to relapse. (Medical News Today)

DNA coils, uncoils, and writhes to drive cell activity
Using a multidisciplinary approach, researchers, led by those at Baylor College of Medicine, revealed in unprecedented detail the three-dimensional structure of biologically active DNA. (Medical News Today)

Prenatal screening test: Independent performance study of the IONA test published
Premaitha Health plc, developer of the IONA® test, the first CE-marked non-invasive prenatal screening test (NIPT), has announced the results of a study on the first-trimester detection of... (Medical News Today)

Supercoiled DNA is far more dynamic than the "Watson-Crick" double helix
Researchers have imaged in unprecedented detail the three-dimensional structure of supercoiled DNA, revealing that its shape is much more dynamic than the well-known double helix. (Medical News Today)

Identification of genetic features in breast cancer subtype may help guide therapy
Building on previous work from The Cancer Genome Atlas Project, a team of researchers comprised of investigators from multiple institutions worldwide has identified genetic features that define a... (Medical News Today)

A man's life behaviors may impact grandchildren's health
Researchers suggest a man's life behaviors may alter a protein found in sperm to influence the health of both his children and grandchildren. (Medical News Today)

Genetic variant shown to influence women's body shape and diabetes risk
A genetic variant near the KLF14 gene regulates hundreds of genes that govern how and where women's bodies store fat, which affects their risk of developing Type 2 diabetes, according to research... (Medical News Today)

Hard-to-detect chromosomal anomalies explain neurodevelopmental birth defects
Balanced chromosomal abnormalities (BCAs), a category of structural changes to the human genome, may account for a large portion of birth defects related to brain development and function, according... (Medical News Today)

A better way to read the genome
If your genome was a library, some genes would be 'Choose Your Own Adventure' novels. (Medical News Today)

New test can predict a man's sexual orientation
Researchers have created an algorithm that identifies genetic changes to predict whether a man is homosexual or heterosexual with up to 70% accuracy. (Medical News Today)

Researchers study costs of integrating genetic sequencing into clinical care
Integrating whole genome sequencing into primary care and heart disease care is unlikely to substantially increase the costs of health care utilization and follow-up tests, according to research... (Medical News Today)

Geneticists reconstruct population history of New York City
By combining genetic data, ancestry information, and electronic health records, scientists are able to identify neighborhood-level patterns of migration in the New York City area, according to... (Medical News Today)

Teens value results of genetic tests to inform future life decisions
The majority of adolescents in grades 7-12 would prefer to know the results of unanticipated findings found in whole exome sequencing genetic testing, even if the findings are not medically... (Medical News Today)

Insight into cancer resistance in elephants could aid human treatment
Elephants rarely develop cancer, and researchers have uncovered new information on why this is in a new study. The findings may shed light on cancer suppression in humans. (Medical News Today)

Researchers create 'leukemia in a dish' to better study it
Scientists engineered stem cells to better understand the mechanisms behind a form of leukemia caused by changes in a key gene, according to a study led by Mount Sinai researchers and published... (Medical News Today)

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